NMR Reveals the Conformational Changes of Cytochrome C upon Interaction with Cardiolipin
 

NMR Reveals the Conformational Changes of Cytochrome C upon Interaction with Cardiolipin

Conformational change of cytochrome c (cyt c) caused by interaction with cardiolipin (CL) is an important step during apoptosis, but the underlying mechanism is controversial. To comprehensively clarify the structural transformations of cyt c upon interaction with CL and avoid the unpredictable alias that might come from protein labeling or mutations, the conformation of purified yeast iso-1 cyt c with natural isotopic abundance in different contents of CL was measured by using NMR spectroscopy,...

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