NMR of Ran complexed with Mengo Leader protein [Microbiology]
 

NMR of Ran complexed with Mengo Leader protein [Microbiology]

Bacot-Davis, V. R., Ciomperlik, J. J., Basta, H. A., Cornilescu, C. C., Palmenberg, A. C....
Date: 2014-11-04

Cardiovirus Leader (L) proteins induce potent antihost inhibition of active cellular nucleocytoplasmic trafficking by triggering aberrant hyperphosphorylation of nuclear pore proteins (Nup). To achieve this, L binds protein RanGTPase (Ran), a key trafficking regulator, and diverts it into tertiary or quaternary complexes with required kinases. The activity of L is... Read More


PNAS:
Number: 44
Volume: 111