NMR and neutron studies of proton transfer [Biochemistry]
 

NMR and neutron studies of proton transfer [Biochemistry]

Michalczyk, R., Unkefer, C. J., Bacik, J.-P., Schrader, T. E., Ostermann, A., Kovalevsky, A. Y., McKenna, R., Fisher, S. Z....
Date: 2015-05-05

Human carbonic anhydrase II (HCA II) uses a Zn-bound OH-/H2O mechanism to catalyze the reversible hydration of CO2. This catalysis also involves a separate proton transfer step, mediated by an ordered solvent network coordinated by hydrophilic residues. One of these residues, Tyr7, was previously shown to be deprotonated in the... Read More


PNAS:
Number: 18
Volume: 112