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Default NMR Meets Tau: Insights into Its Function and Pathology.

NMR Meets Tau: Insights into Its Function and Pathology.

NMR Meets Tau: Insights into Its Function and Pathology.

Biomolecules. 2016;6(2)

Authors: Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J

Abstract
In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.


PMID: 27338491 [PubMed - in process]



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