NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates
 

NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates

The spatial and temporal organization of interactions between proteins underlie the regulation of most cellular processes. The requirement for such interactions to be specific predisposes a view that protein-protein interactions are relatively static and are formed through the stable complementarity of the interacting partners. A growing body of reports indicate, however, that many interactions lead to fuzzy complexes with an ensemble of conformations in dynamic exchange accounting for the...

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