NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission [Biophysics and Computational Biology]
 

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission [Biophysics and Computational Biology]

Mukesh Mahajan, Nikhil Bharambe, Yutong Shang, Bin Lu, Abhishek Mandal, Pooja Madan Mohan, Rihua Wang, Jennifer C. Boatz, Juan Manuel Martinez Galvez, Anna V. Shnyrova, Xin Qi, Matthias Buck, Patrick C. A. van der Wel, Rajesh Ramachandran...
Date: 2021-07-14

Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion. Emerging evidence suggests that a direct yet unresolved interaction of the mechanoenzymatic GTPase dynamin-related protein 1 (Drp1) with mitochondrial outer membrane–localized cardiolipin (CL), externalized under stress conditions including mitophagy, catalyzes essential mitochondrial hyperfragmentation. Here, using a comprehensive set... Read More


PNAS:
Number: 29
Volume: 118