NMR hawk-eyed view of AlphaFold2 structures
 

NMR hawk-eyed view of AlphaFold2 structures

The prediction of the three-dimensional structure of proteins from the amino acid sequence made a stunning breakthrough reaching atomic accuracy. Using the neural network-based method AlphaFold2 three-dimensional structures of almost the entire human proteome have been predicted and made available (https://www.alphafold.ebi.ac.uk). To gain insight into how well AlphaFold2 structures represent the conformation of proteins in solution, I here compare the AlphaFold2 structures of selected small...

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