NMR and functional study of eIF4E3 [Biophysics and Computational Biology]
 

NMR and functional study of eIF4E3 [Biophysics and Computational Biology]

Osborne, M. J., Volpon, L., Kornblatt, J. A., Culjkovic-Kraljacic, B., Baguet, A., Borden, K. L. B....
Date: 2013-03-05

Recognition of the methyl-7-guanosine (m7G) cap structure on mRNA is an essential feature of mRNA metabolism and thus gene expression. Eukaryotic translation initiation factor 4E (eIF4E) promotes translation, mRNA export, proliferation, and oncogenic transformation dependent on this cap-binding activity. eIF4E–cap recognition is mediated via complementary charge interactions of the positively... Read More


PNAS:
Number: 10
Volume: 110