[NMR paper] NMR-based Lavado cocoa chemical characterization and comparison with fermented cocoa varieties: Insights on cocoa's anti-amyloidogenic activity.
Related ArticlesNMR-based Lavado cocoa chemical characterization and comparison with fermented cocoa varieties: Insights on cocoa's anti-amyloidogenic activity.
Food Chem. 2021 Mar 30;341(Pt 2):128249
Authors: Ciaramelli C, Palmioli A, De Luigi A, Colombo L, Sala G, Salmona M, Airoldi C
Abstract
The metabolic profile of Lavado cocoa was characterized for the first time by NMR spectroscopy, then compared with the profiles of fermented and processed varieties, Natural and commercial cocoa. The significant difference in the contents of theobromine and flavanols prompted us to examine the cocoa varieties to seek correlations between these metabolite concentrations and the anti-amyloidogenic activity reported for cocoa in the literature. We combined NMR spectroscopy, preparative reversed-phase (RP) chromatography, atomic force microscopy, in vitro biochemical and cell assays, to investigate and compare the anti-amyloidogenic properties of extracts and fractions enriched in different metabolite classes. Lavado variety was the most active and the catechins and theobromine were the chemical components of cocoa hindering A? peptide on-pathway aggregation and toxicity in a human neuroblastoma SH-SY5Y cell line.
[NMR paper] [Anti-inflammatory mechanism of Crepis crocea based on NF-?B signaling pathway and ~1H-NMR metabonomics].
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Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(4):946-954
Authors: Miao YL, He P, Zhang WX, Zhang WZ, Feng M, Ni Y
Abstract
Based on ~1H-NMR metabonomics technique and Western blot assay, the anti-inflammatory mechanism of Crepis crocea was discussed. In this study, male SD rats were treated with water extract(2.5 g·kg~(-1)) and dexamethasone acetate(6.25×10~(-4) g·kg~(-1)) for one week, and the inflammation model was induced by lipopolysaccharide(LPS). Then the counts of inflammatory cells white blood ceel(WBC),...
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[NMR paper] Biochemical characterization and (1)H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats.
Biochemical characterization and (1)H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.biomedcentral.com-graphics-pubmed-BioMedCentral_free_1.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Biochemical characterization and (1)H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats.
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09-03-2017 02:09 AM
[NMR paper] Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR
Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR
Publication date: July 2017
Source:Journal of Magnetic Resonance, Volume 280</br>
Author(s): Jobin Varkey, Ralf Langen</br>
The advancement in site-directed spin labeling of proteins has enabled EPR studies to expand into newer research areas within the umbrella of protein-membrane interactions. Recently, membrane remodeling by amyloidogenic and non-amyloidogenic proteins has gained a substantial interest in relation to driving and controlling vital cellular processes such as...
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[NMR paper] Characterization of red/green cyanobacteriochrome NpR6012g4 by solution NMR spectroscopy: a hydrophobic pocket for the C15-E,anti chromophore in the photoproduct.
Characterization of red/green cyanobacteriochrome NpR6012g4 by solution NMR spectroscopy: a hydrophobic pocket for the C15-E,anti chromophore in the photoproduct.
Related Articles Characterization of red/green cyanobacteriochrome NpR6012g4 by solution NMR spectroscopy: a hydrophobic pocket for the C15-E,anti chromophore in the photoproduct.
Biochemistry. 2015 May 20;
Authors: Rockwell NC, Martin SS, Lim S, Lagarias JC, Ames JB
Abstract
Cyanobacteriochromes (CBCRs) are cyanobacterial photosensory proteins distantly related to...
[NMR paper] The proteolysis process in fermented sausage model systems as studied by nmr relaxometry.
THE PROTEOLYSIS PROCESS IN FERMENTED SAUSAGE MODEL SYSTEMS AS STUDIED BY NMR RELAXOMETRY.
Related Articles THE PROTEOLYSIS PROCESS IN FERMENTED SAUSAGE MODEL SYSTEMS AS STUDIED BY NMR RELAXOMETRY.
J Agric Food Chem. 2015 Mar 9;
Authors: Garcia AB, Larsen LB, Cambero MI, Diaz KP, Bertram HC
Abstract
Proton NMR relaxation analyses were performed in sausage model systems (SMS) at different manufacturing times (0, 1, 3, 5, 7 and 9 days) to evaluate changes in water distribution and mobility. Three different water populations were...
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03-10-2015 07:22 PM
Metabolic characterization of Palatinate German white wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses
Metabolic characterization of Palatinate German white wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses
Abstract 1H NMR (nuclear magnetic resonance spectroscopy) has been used for metabolomic analysis of â??Rieslingâ?? and â??Mueller-Thurgauâ?? white wines from the German Palatinate region. Diverse two-dimensional NMR techniques have been applied for the identification of metabolites, including phenolics. It is shown that sensory analysis correlates with NMR-based metabolic profiles of wine. 1H NMR data in combination...
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[NMR paper] Characterization of the structure and dynamics of amyloidogenic variants of human lys
Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
Related Articles Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.
Protein Sci. 2001 Dec;10(12):2525-30
Authors: Chamberlain AK, Receveur V, Spencer A, Redfield C, Dobson CM
The structures and dynamics of the native states of two mutational variants of human lysozyme, I56T and D67H, both associated with non-neuropathic systemic amyloidosis, have been investigated by NMR...
NMR-based Lavado cocoa chemical characterization and comparison with fermented cocoa varieties: Insights on cocoa's anti-amyloidogenic activity.
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