NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.
 

NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.

Related Articles NMR backbone resonance assignment of New Delhi metallo-beta-lactamase.

Biomol NMR Assign. 2017 Aug 14;:

Authors: Yao C, Wu Q, Xu G, Li C

Abstract
The emerging of the New Delhi metallo-beta-lactamase (NDM-1) has become one of the greatest threats to the clinical treatment. Although the structure of NDM-1 has been determined by X-ray crystallography, the molecular mechanism and process of catalysis reaction remain elusive. NMR spectroscopy plays a unique role in the characterization of conformational dynamics. Here we report the backbone (1)H, (15)N and (13)C chemical shift assignments of NDM-1 by heteronuclear multidimensional NMR spectroscopy as well as its secondary structure in solution as predicted by TALOS+.


PMID: 28808891 [PubMed - as supplied by publisher]



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