NMR {Delta}{delta}NH/{Delta}T to design orally bioavailable peptides [Biophysics and Computational Biology]
 

NMR {Delta}{delta}NH/{Delta}T to design orally bioavailable peptides [Biophysics and Computational Biology]

Wang, C. K., Northfield, S. E., Colless, B., Chaousis, S., Hamernig, I., Lohman, R.-J., Nielsen, D. S., Schroeder, C. I., Liras, S., Price, D. A., Fairlie, D. P., Craik, D. J....
Date: 2014-12-09

Enhancing the oral bioavailability of peptide drug leads is a major challenge in drug design. As such, methods to address this challenge are highly sought after by the pharmaceutical industry. Here, we propose a strategy to identify appropriate amides for N-methylation using temperature coefficients measured by NMR to identify exposed... Read More


PNAS:
Number: 49
Volume: 111