New structural insights into carbohydrate-protein interactions from NMR spectroscopy.
 

New structural insights into carbohydrate-protein interactions from NMR spectroscopy.

Related Articles New structural insights into carbohydrate-protein interactions from NMR spectroscopy.

Curr Opin Struct Biol. 2003 Oct;13(5):646-53

Authors: Kogelberg H, Solís D, Jiménez-Barbero J

Recently developed NMR methods have been applied to discover carbohydrate ligands for proteins and to identify their binding epitopes. The structural details of carbohydrate-protein complexes have also been examined by NMR, providing site-specific information on the architecture, binding selectivity and plasticity of the carbohydrate-binding sites of the proteins. New insights into the conformational behaviour of free and protein-bound glycomimetics pave the way for the design of carbohydrate-based therapeutics. Finally, recent progress towards elucidating the influence of glycosylation on peptide conformation will be of key importance to fully understanding the role of carbohydrates in the function of glycopeptides.

PMID: 14568621 [PubMed - indexed for MEDLINE]



Source: PubMed