Benzimidazole derivatives are known to be key players in the development of novel anticancer agents. Herein, we aimed to synthesize novel derivatives to target breast cancer. A new series of benzimidazole derivatives conjugated with either six- and five-membered heterocyclic ring or pyrazanobenzimidazoles and pyridobenzimidazole linkers were synthesized yielding compounds 5-8 and 10-14, respectively. Structure elucidation of the newly synthesized compounds was achieved through microanalytical...
Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures
From The DNP-NMR Blog:
Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures
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Harris, T., H. Degani, and L. Frydman, Hyperpolarized 13C NMR studies of glucose metabolism in living breast cancer cell cultures. NMR Biomed, 2013. 26(12): p. 1831-43.
https://www.ncbi.nlm.nih.gov/pubmed/24115045
[NMR paper] Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhib
Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Related Articles Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.
Bioorg Med Chem Lett. 2001 Jul 9;11(13):1665-9
Authors: Sundaramoorthi R, Siedem C, Vu CB, Dalgarno DC, Laird EC, Botfield MC, Combs AB, Adams SE, Yuan RW, Weigele M, Narula SS
Detailed analysis of Src SH2 binding by peptides containing a...
New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies
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