The N-Terminal Domain of Abeta(40)-Amyloid Fibril: The MOMD Perspective of its Dynamic Structure from NMR Lineshape Analysis
 

The N-Terminal Domain of Abeta(40)-Amyloid Fibril: The MOMD Perspective of its Dynamic Structure from NMR Lineshape Analysis

We have developed the stochastic microscopic-order-macroscopic-disorder (MOMD) approach for elucidating dynamic structures in the solid-state from ²H NMR lineshapes. In MOMD, the probe experiences an effective/collective motional mode. The latter is described by a potential, u, which represents the local spatial-restrictions, a local-motional diffusion tensor, R, and key features of local geometry. Previously we applied MOMD to the well-structured core domain of the 3-fold-symmetric twisted...

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