[NMR paper] Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Related ArticlesMetabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
PLoS One. 2013;8(6):e65675
Authors: Wang L, Tang Y, Liu S, Mao S, Ling Y, Liu D, He X, Wang X
Abstract
Chronic obstructive pulmonary disease (COPD) has seriously impacted the health of individuals and populations. In this study, proton nuclear magnetic resonance ((1)H NMR)-based metabonomics combined with multivariate pattern recognition analysis was applied to investigate the metabolic signatures of patients with COPD. Serum and urine samples were collected from COPD patients (n = 32) and healthy controls (n = 21), respectively. Samples were analyzed by high resolution (1)H NMR (600 MHz), and the obtained spectral profiles were then subjected to multivariate data analysis. Consistent metabolic differences have been found in serum as well as in urine samples from COPD patients and healthy controls. Compared to healthy controls, COPD patients displayed decreased lipoprotein and amino acids, including branched-chain amino acids (BCAAs), and increased glycerolphosphocholine in serum. Moreover, metabolic differences in urine were more significant than in serum. Decreased urinary 1-methylnicotinamide, creatinine and lactate have been discovered in COPD patients in comparison with healthy controls. Conversely, acetate, ketone bodies, carnosine, m-hydroxyphenylacetate, phenylacetyglycine, pyruvate and ?-ketoglutarate exhibited enhanced expression levels in COPD patients relative to healthy subjects. Our results illustrate the potential application of NMR-based metabonomics in early diagnosis and understanding the mechanisms of COPD.
[NMR paper] 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
Chem Biol Interact. 2013 May 25;203(3):588-96
Authors: Wang HP, Liang YJ, Sun YJ, Chen JX,...
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07-17-2013 12:00 PM
[NMR paper] Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Int J Endocrinol Metab. 2012;10(3):548-552
Authors: Rezaei-Tavirani M, Fathi F, Darvizeh F, Zali MR, Rostami Nejad M, Rostami K, Tafazzoli M, Arefi Oskouie A, Mortazavi-Tabatabaei SA
Abstract
BACKGROUND: Celiac disease (CD) is a disorder associated with body reaction to gluten. After the gluten intake, an immune reaction against the protein occurs and damages villi of small...
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07-12-2013 06:01 PM
[NMR paper] (1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
(1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
(1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
J Pharm Biomed Anal. 2013 Apr 22;83C:43-48
Authors: Deja S, Barg E, M?ynarz P, Basiak A, Willak-Janc E
Abstract
The aim of this study was to investigate relation between level of HbAc1 and concentration of metabolites in urine of T1D patients. To test this hypothesis the (1)H NMR...
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05-25-2013 12:05 PM
[NMR paper] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
Related Articles NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
J Clin Biochem Nutr. 2013 Mar;52(2):133-8
Authors: Fukuhara K, Ohno A, Ota Y, Senoo Y, Maekawa K, Okuda H, Kurihara M, Okuno A, Niida S, Saito Y, Takikawa O
Abstract
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker...
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03-26-2013 01:30 PM
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
J Nutr Biochem. 2011 Mar 21;
Authors: He Q, Ren P, Kong X, Wu Y, Wu G, Li P, Hao F, Tang H, Blachier F, Yin Y
Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean...
Nobel Laureate Presents Chronic Wasting Disease Lecture at UW - University of Wyoming
Nobel Laureate Presents Chronic Wasting Disease Lecture at UW - University of Wyoming News
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University of Wyoming News
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Nobel Laureate Presents Chronic Wasting Disease Lecture at UW
University of Wyoming News
His research interests include molecular structural biology, protein science and structural genomics with an emphasis on using nuclear magnetic resonance ...
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
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