Metabolic profiling of colorectal cancer organoids: a comparison between HR MAS MRS and solution NMR spectroscopy of polar extracts
 

Metabolic profiling of colorectal cancer organoids: a comparison between HR MAS MRS and solution NMR spectroscopy of polar extracts

Patient-derived cancer cells cultured in vitro is a cornerstone for cancer metabolism research. More recently, the introduction of organoids has provided the research community with a more versatile model system. Physiological structure and organization of the cell source tissue is maintained in organoids, representing a closer link to in vivo tumor models. High resolution magic angle spinning MR spectroscopy (HR MAS MRS) is a commonly applied analytical approach for metabolic profiling of...

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