Related ArticlesMetabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.
J Radiat Res. 2020 Jan 23;61(1):14-26
Authors: Gramatyka M, Boguszewicz ?, Ciszek M, Gabry? D, Kulik R, Sokó? M
Abstract
Ionizing radiation may cause cardiotoxicity not only at high, but even at low (considered as harmless) doses, yet the molecular mechanisms of the heart's response to low doses are not clear. In this work, we used high-resolution nuclear magnetic resonance (NMR) spectroscopy to detect the early and late effects of radiation on the metabolism of murine hearts. The hearts of C57Bl/6NCrl female mice were irradiated in vivo with single 0.2*Gy or 2*Gy doses using 6 MV photons, then tissues were collected 48*h and 20*weeks after exposure. The most distinct changes in the profile of polar metabolites were detected 48*h after irradiation with 2*Gy, and included increased levels of pantothenate and glutamate as well as decreased levels of alanine, malonate, acetylcarnitine, glycine and adenosine. Significant effects of the 2*Gy dose were also observed 20*weeks after irradiation and included decreased levels of glutamine and acetylcarnitine when compared with age-matched controls. Moreover, several differences were observed between hearts irradiated with 2*Gy and analyzed either 48*h or 20*weeks after the exposure, which included changes in levels of acetylcarnitine, alanine, glycine, glutamate, glutamine, formate, myo-inositol and trimethylamine. No statistically significant effects induced by the 0.2*Gy dose were observed 20*weeks after irradiation. In general, radiation-affected compounds were associated with energy metabolism, fatty acid beta-oxidation, oxidative stress and damage to cell structures. At the same time, radiation-related effects were not detected at the level of tissue histology, which indicated a higher sensitivity of metabolomics-based tests for cardiac tissue response to radiation.
[NMR paper] NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer.
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Clin Chim Acta. 2020 Feb;501:241-251
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Metab Brain Dis. 2018 10;33(5):1661-1668
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Alzheimer's disease (AD) has been...
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[NMR paper] Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using (1)H HR-MAS NMR spectroscopy.
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Abstract
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer's disease (AD) are not fully understood. However, alterations of glucose metabolism and...
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Metabolic profiling of vitamin C deficiency in Guloâ??/â?? mice using proton NMR spectroscopy
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Abstract Nutrient deficiencies are an ongoing problem in many populations and ascorbic acid is a key vitamin whose mild or acute absence leads to a number of conditions including the famously debilitating scurvy. As such, the biochemical effects of ascorbate deficiency merit ongoing scrutiny, and the Gulo knockout mouse provides a useful model for the metabolomic examination of vitamin C deficiency. Like humans, these animals are incapable of synthesizing ascorbic acid but with dietary...
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Magn Reson Med. 2001 Aug;46(2):249-55
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Dystrophin, a protein associated with sarcolemma and cell membranes, is not expressed in sufferers of Duchenne muscular dystrophy (DMD), or in the mdx mouse....
Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.
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