Membrane Protein Structures in Native Cellular Membranes Revealed by Solid-State NMR Spectroscopy
 

Membrane Protein Structures in Native Cellular Membranes Revealed by Solid-State NMR Spectroscopy

The structural characterization of membrane proteins within the cellular membrane environment is critical for understanding the molecular mechanism in their native functional context. However, conducting residue site-specific structural analysis of membrane proteins in native membranes by solid-state NMR faces challenges due to poor spectral sensitivity and serious interference from background protein signals. In this study, we present a new protocol that combines various strategies for cellular...

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