From medium to endoplasmic reticulum: Tracing anticancer phenolato titanium(IV) complex by (19)F NMR detection
 

From medium to endoplasmic reticulum: Tracing anticancer phenolato titanium(IV) complex by (19)F NMR detection

Titanium(IV) complexes of diaminobis(phenolato)-bis(alkoxo) ligands are promising anticancer drugs, showing marked in-vivo efficacy with no toxic side-effects in mice, hence, it is of interest to elucidate their mechanism of action. Herein, we employed a fluoro-substituted derivative, FenolaTi, for mechanistic analysis of the active species and its cellular target by quantitative ^(19)F NMR detection to reveal its biodistribution and reactivity in extracellular and intracellular matrices. Upon...

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