Magic angle spinning NMR of viruses.
 

Magic angle spinning NMR of viruses.

Related Articles Magic angle spinning NMR of viruses.

Prog Nucl Magn Reson Spectrosc. 2015 Apr;86-87C:21-40

Authors: Quinn CM, Lu M, Suiter CL, Hou G, Zhang H, Polenova T

Abstract
Viruses, relatively simple pathogens, are able to replicate in many living organisms and to adapt to various environments. Conventional atomic-resolution structural biology techniques, X-ray crystallography and solution NMR spectroscopy provided abundant information on the structures of individual proteins and nucleic acids comprising viruses; however, viral assemblies are not amenable to analysis by these techniques because of their large size, insolubility, and inherent lack of long-range order. In this article, we review the recent advances in magic angle spinning NMR spectroscopy that enabled atomic-resolution analysis of structure and dynamics of large viral systems and give examples of several exciting case studies.


PMID: 25919197 [PubMed - as supplied by publisher]



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