Related ArticlesNMR backbone resonance assignments of the prodomain variants of BDNF in the urea denatured state.
Biomol NMR Assign. 2017 Sep 20;:
Authors: Wang J, Bains H, Anastasia A, Bracken C
Abstract
Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of proteins which plays a central role in neuronal survival, growth, plasticity and memory. A single Val66Met variant has been identified in the prodomain of human BDNF that is associated with anxiety, depression and memory disorders. The structural differences within the full-length prodomain Val66 and Met66 isoforms could shed light on the mechanism of action of the Met66 and its impact on the development of neuropsychiatric-associated disorders. In the present study, we report the backbone (1)H, (13)C, and (15)N NMR assignments of both full-length Val66 and Met66 prodomains in the presence of 2*M urea. These conditions were utilized to suppress residual structure and aid subsequent native state structural investigations aimed at mapping and identifying variant-dependent conformational differences under native-state conditions.
PMID: 28933046 [PubMed - as supplied by publisher]
[NMR paper] Backbone NMR assignments of a topologically knotted protein in urea-denatured state.
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Biomol NMR Assign. 2013 Jul 14;
Authors: Hsieh SJ, Mallam AL, Jackson SE, Hsu ST
Abstract
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[NMR paper] Backbone NMR assignments of a topologically knotted protein in urea-denatured state.
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Biomol NMR Assign. 2013 Jul 3;
Authors: Hsieh SJ, Mallam AL, Jackson SE, Hsu ST
Abstract
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http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Structural and dynamic characterization of the urea denatured state of the immunoglobulin binding domain of streptococcal...
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NMR backbone resonance assignments of the prodomain variants of BDNF in the urea denatured state.
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