[NMR paper] Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease.
Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease.
Related ArticlesLaparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease.
Sci Rep. 2021 Jan 14;11(1):1343
Authors: Cabré N, Gil M, Amigó N, Luciano-Mateo F, Baiges-Gaya G, Fernández-Arroyo S, Rodríguez-Tomàs E, Hernández-Aguilera A, Castañé H, París M, Sabench F, Del Castillo D, Camps J, Joven J
Abstract
Patients with morbid obesity frequently present non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) associated with pro-atherogenic alterations. Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for weight reduction, and for the remission of hepatic alterations. Using 1H-nuclear magnetic resonance (1H-NMR), we investigated the effects of LSG on lipoprotein and glycoprotein profile in patients with morbid obesity and liver disease. We included 154 patients with morbid obesity (49 non-NASH, 54 uncertain NASH, 51 definite NASH). A blood sample was obtained before surgery and, in patients with definite NASH, one year after surgery. Patients with NASH had increased concentrations of medium and small VLDL particles, VLDL and IDL cholesterol concentrations, IDL, LDL, and HDL triglyceride concentrations, and elevated glycoprotein levels. These changes were more marked in patients with type 2 diabetes mellitus. LSG produced significant decreases in the concentration of VLDL particles, VLDL cholesterol and triglycerides, an increase in the concentration LDL particles and LDL cholesterol concentrations, and a decrease in protein glycation. We conclude that patients with obesity and NASH had significant alterations in circulating levels of lipoproteins and glycoproteins that were associated with the severity of the disease. Most of these changes were reversed post-LSG.
[NMR paper] Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay.
Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay.
Related Articles Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay.
J Clin Med. 2020 Sep 10;9(9):
Authors: Bedi S, Garcia E, Jeyarajah EJ, Shalaurova I, Perez-Matos MC, Jiang ZG, Dullaart RPF, Matyus SP, Kirk WJ, Otvos JD, Davidson WS, Connelly MA
Abstract
BACKGROUND: Lipoprotein particles with abnormal...
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[NMR paper] Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients.
Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.nature.com-images-lo_npg.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.png Related Articles Sex differences in the 1H NMR metabolic profile of serum in cardiovascular risk patients.
Sci Rep. 2019 02 20;9(1):2380
Authors: Barba I, Andrés M, Picón I, Aguade-Bruix S, Garcia-Dorado D
Abstract
...
[NMR paper] Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study.
Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study.
Related Articles Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study.
J Clin Med. 2020 May 04;9(5):
Authors: Malo AI, Rull A, Girona J, Domingo P, Fuertes-Martín R, Amigó N, Rodríguez-Borjabad C, Martínez-Micaelo N, Leal M, Peraire J, Correig X, Vidal F, Masana L
Abstract
Plasma glycoproteins are a composite biomarker of inflammation...
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05-08-2020 06:11 PM
[NMR paper] The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes.
The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--s3-service-broker-live-ddda94b7-dbb0-4917-917d-776dae91ebba.s3.amazonaws.com-bmc-linkout-fulltext.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by...
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02-27-2018 12:30 PM
Can-Fite on go with mid-stage study of namodenoson in fatty liver disease - Seeking Alpha
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Can-Fite on go with mid-stage study of namodenoson in fatty liver disease
Seeking Alpha
The primary endpoint will be the percent change from baseline in liver triglyceride concentration as measured by nuclear magnetic resonance spectroscopy. Namodenoson, formerly CF102, is an orally available small molecule that binds to a protein that is ...
Can-Fite BioPharma (CANF) Says Phase II NAFLD/NASH Trial with Namodenoson Set to Commence Patient ...StreetInsider.com
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Can-Fite on go with mid-stage study of namodenoson in fatty...
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07-18-2017 07:52 AM
Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms - Huntington's Disease News
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Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms
Huntington's Disease News
Researchers at the University of Pittsburgh School of Medicine used advanced nuclear magnetic resonance spectroscopy to directly assess and characterize huntingtin fibrils and other polyglutamine aggregates. Results showed that, unlike what previous ...
Protein Plaques in Huntington's Patients Have Distinct Structures That Hint at Disease Mechanisms - Huntington's Disease News
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02-06-2016 03:05 AM
[NMR paper] Interaction of chicken liver basic fatty acid-binding protein with fatty acids: a 13C
Interaction of chicken liver basic fatty acid-binding protein with fatty acids: a 13C NMR and fluorescence study.
Related Articles Interaction of chicken liver basic fatty acid-binding protein with fatty acids: a 13C NMR and fluorescence study.
Biochemistry. 2001 Oct 23;40(42):12604-11
Authors: Beringhelli T, Goldoni L, Capaldi S, Bossi A, Perduca M, Monaco HL
Two different groups of liver fatty acid-binding proteins (L-FABPs) are known: the mammalian type and the basic type. Very few members of this second group of L-FABPs have been...
Laparoscopic sleeve gastrectomy alters 1H-NMR-measured lipoprotein and glycoprotein profile in patients with severe obesity and nonalcoholic fatty liver disease.
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