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Ab initio:
GeNMR
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Fragment-based:
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Refinement:
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Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
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Homology-based:
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Torsion angles from chemical shifts:
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Secondary structure from chemical shifts:
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Flexibility from chemical shifts:
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Interactions from chemical shifts:
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Chemical shifts re-referencing:
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Chemical shifts prediction:
From structure:
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PPM
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From sequence:
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Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
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NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
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Isotope labeling:
UPLABEL
Solid-state NMR:
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Default Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques.

Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques.

Related Articles Interactions of Polyphenols with Plasma Proteins: Insights from Analytical Techniques.

Curr Drug Metab. 2013 Jan 17;

Authors: Jaldappagari S, Balakrishnan S, Hegde AH, Teradal NL, Narayan PS

Abstract
Phenolic compounds are commonly found in natural sources like plant-based foods and beverages.* These compounds have received much attention due to their unique biological properties. Polyphenols possess a significant binding affinity for serum albumins which are known to be principal extracellular proteins with a high concentration in blood plasma.* They act as carriers of several drugs to different molecular targets.* This review summarizes the salient features of the reported work on polyphenol-protein interactions by analytical methods viz., chromatography, circular dichroism, fluorescence spectroscopy (steady state and time resolved), light scattering, equilibrium dialysis, differential scanning calorimetry, UV-vis spectroscopy, isothermal calorimetry, MALDI-TOF mass spectrometry, size exclusion chromatography, capillary electrophoresis, electrospray ionization mass spectrometry, FT-IR, molecular modelling, HPLC, NMR, cyclic voltammetry etc.* Polyphenol-serum albumin interaction studies assume significance from the view point of pharmacokinetics and pharmacodynamics.


PMID: 23330930 [PubMed - as supplied by publisher]



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