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-   -   [NMR paper] Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy (http://www.bionmr.com/forum/journal-club-9/interactions-between-s100a9-alpha-synuclein-insight-nmr-spectroscopy-29221/)

nmrlearner 06-24-2022 11:45 PM

Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy
 
Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy

S100A9 is a pro-inflammatory protein that co-aggregates with other proteins in amyloid fibril plaques. S100A9 can influence the aggregation kinetics and amyloid fibril structure of alpha-synuclein (?-syn), which is involved in Parkinson's disease. Currently, there are limited data regarding their cross-interaction and how it influences the aggregation process. In this work, we analyzed this interaction using solution 19F and 2D ^(15)N-¹H HSQC NMR spectroscopy and studied the aggregation...

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