The influence of fatty acids on metoprolol - human serum albumin interaction in low affinity binding sites: a multifactorial NMR approach.
 

The influence of fatty acids on metoprolol - human serum albumin interaction in low affinity binding sites: a multifactorial NMR approach.

Related Articles The influence of fatty acids on metoprolol - human serum albumin interaction in low affinity binding sites: a multifactorial NMR approach.

Protein Pept Lett. 2018 Jan 15;:

Authors: Szkudlarek A, Mogielnicki M, Pentak D, Ploch A, Maciazek-Jurczyk M

Abstract
The aim of the study was to evaluate the mechanism of interaction between metoprolol (MTP) and human serum albumin (HSA) using 1H NMR technique. The analysis of the drug-albumin interaction was based on the observed chemical shifts in combination with correlation times, 2D NOESY 1H NMR spectra and association constants and allowed us to observe the interactions between the aromatic rings of the drug and the amino acids of the protein. The binding of the drug, both in the hydrophobic subdomain and on the surface of the albumin, increases in the presence of fatty acids (FAs).


PMID: 29336242 [PubMed - as supplied by publisher]



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