Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective.
 

Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective.

Related Articles Heparin-Binding Proteins (Chemokines and Defensins) and their Complexes with Glycosaminoglycans from the Solution NMR Perspective.

Curr Protein Pept Sci. 2014 Aug 25;

Authors: Pomin VH

Abstract
This review paper aims at discussing the major recent achievements in the field of the heparin-binding proteins (HBPs), primarily chemokines and defensins, and their complexes with glycosaminoglycans examined by the solution nuclear magnetic resonance (NMR) spectroscopy. As opposed to the HBPs involved in coagulation (mainly antithrombin and thrombin), and growth factors (especially fibroblast growth factors 1 and 2), which were extensively analyzed in the past, inflammatory chemokines turned out to be the most thoroughly studied HBPs nowadays. Defensins, which structurally and functionally resemble the chemokines, are also under intensive current investigation.


PMID: 25175334 [PubMed - as supplied by publisher]



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