Glycerol and Glycerol Carbonate as ultraviscous solvents for mixture analysis by NMR

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Glycerol and Glycerol Carbonate as ultraviscous solvents for mixture analysis by NMR

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07-03-2011, 05:40 AM

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Glycerol and Glycerol Carbonate as ultraviscous solvents for mixture analysis by NMR

Glycerol and Glycerol Carbonate as ultraviscous solvents for mixture analysis by NMR

Publication year: 2011
Source: Journal of Magnetic Resonance, In Press, Accepted Manuscript, Available online 1 July 2011

Pedro, Lameiras , Leslie, Boudesocque , Zéphirin, Mouloungui , Jean-Hugues, Renault , Jean-Michel, Wieruszeski , ...

NMR of weakly polar analytes in an apolar ultraviscous solvent has recently been proposed for mixture analysis as a pertinent alternative to the DOSY experiment. The present article reports the first use of glycerol and glycerol carbonate as polar solvents for the NMR analysis of a model mixture of dipeptides. This work demonstrates the high potentiality of these solvents for the analysis of mixtures made of polar and potentially bioactive compounds. Medium-sized molecules slowly reorient in glycerol and glycerol carbonate under particular temperature conditions, so that solute resonances may show spin diffusion in NOESY spectra, thus opening the way to...

Graphical abstract

*Graphical abstract:**Highlights:*? Medium-sized molecules slowly reorient in GL and GC and therefore may be individualized by spin diffusion. ? GL and GC appeared to be ultraviscous solvents of choice for the characterization of four structurally close dipeptides. ? Selective excitation and detection were implemented to eliminate the intense proton signals of the non-deuterated solvents.

Source: Journal of Magnetic Resonance

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