Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
J Proteome Res. 2014 Dec 22;
Authors: Pinto J, Barros AS, Domingues MR, Goodfellow BJ, Galhano E, Pita C, Almeida MD, Carreira IM, Gil AM
Abstract
This paper presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy was confirmed with six amino acids being identified as required by the fetus in larger extents. Newly observed changes in citrate, lactate and dimethyl sulfone suggested early adjustments in energy and gut microflora metabolisms. Alterations in creatine levels were also noted, in addition to creatinine variations reflecting alterations in glomerular filtration rate. Regarding plasma macromolecules, HDL and LDL+VLDL levels were confirmed to increase throughout pregnancy, although at different rates and accompanied by increases in fatty acid chain length and degree of unsaturation. Correlation studies suggested a) an inverse relationship between lipoproteins (HDL and LDL+VLDL) and albumin, with a possible direct correlation to excreted (unassigned) pregnancy markers resonating at ? 0.55 and ? 0.63; b) a direct link between LDL+VLDL and N-acetyl-glycoproteins, together with excreted marker at ? 0.55 and c) correlation of plasma albumin with particular circulating and excreted metabolites. These results have unveiled specific lipoprotein/protein metabolic aspects of pregnancy with impact on the excreted metabolome and, therefore, provide an interesting lead for the further understanding of pregnancy metabolism.
PMID: 25529102 [PubMed - as supplied by publisher]
[NMR paper] Human plasma stability during handling and storage: impact on NMR metabolomics.
Human plasma stability during handling and storage: impact on NMR metabolomics.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles Human plasma stability during handling and storage: impact on NMR metabolomics.
Analyst. 2014 Mar 7;139(5):1168-77
Authors: Pinto J, Domingues MR, Galhano E, Pita C, Almeida Mdo C, Carreira IM, Gil AM
Abstract
This work contributes to fill in some existing gaps in the knowledge of human plasma degradability...
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[NMR paper] Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses.
Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses.
Related Articles Protein catabolism and high lipid metabolism associated with long-distance exercise are revealed by plasma NMR metabolomics in endurance horses.
PLoS One. 2014;9(3):e90730
Authors: Le Moyec L, Robert C, Triba MN, Billat VL, Mata X, Schibler L, Barrey E
Abstract
During long distance endurance races, horses undergo high physiological and metabolic stresses. The adaptation processes...
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03-25-2014 11:49 AM
[NMR paper] Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy...
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[NMR paper] (1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
(1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
(1)H NMR-based metabolomics studies of urine reveal differences between type 1 diabetic patients with high and low HbAc1 values.
J Pharm Biomed Anal. 2013 Apr 22;83C:43-48
Authors: Deja S, Barg E, M?ynarz P, Basiak A, Willak-Janc E
Abstract
The aim of this study was to investigate relation between level of HbAc1 and concentration of metabolites in urine of T1D patients. To test this hypothesis the (1)H NMR...
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05-25-2013 12:05 PM
[NMR paper] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
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J Clin Biochem Nutr. 2013 Mar;52(2):133-8
Authors: Fukuhara K, Ohno A, Ota Y, Senoo Y, Maekawa K, Okuda H, Kurihara M, Okuno A, Niida S, Saito Y, Takikawa O
Abstract
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker...
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03-26-2013 01:30 PM
1H NMR Metabolomics Study of Human Urine
1H NMR Metabolomics Study of Human Urine
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1H NMR Metabolomics Study of Human Urine
A presentation of some recent work from the Metabolomics and Bioinformatics & Statistics Groups at the Institute of Food Research, Norwich, UK. See the teams' webpages at: www.ifr.ac.uk and www.ifr.ac.uk This video is a shortened version of a presentation given at "Advances in Metabolic Profiling 2011".
From:BioStatsXtra
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07-30-2012 07:42 AM
The application of micro-coil NMR probe technology to metabolomics of urine and serum
The application of micro-coil NMR probe technology to metabolomics of urine and serum
Abstract Increasing the sensitivity and throughput of NMR-based metabolomics is critical for the continued growth of this field. In this paper the application of micro-coil NMR probe technology was evaluated for this purpose. The most commonly used biofluids in metabolomics are urine and serum. In this study we examine different sample limited conditions and compare the detection sensitivity of the micro-coil with a standard 5 mm NMR probe. Sample concentration is evaluated as a means to leverage the...
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03-09-2011 04:19 AM
[NMR paper] 1H NMR studies of reactions of copper complexes with human blood plasma and urine.
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Biochem Pharmacol. 1992 Jan 22;43(2):137-45
Authors: Bligh SW, Boyle HA, McEwen AB, Sadler PJ, Woodham RH
Reactions of the copper complexes Cu(II)Cl2, 2-, and + (where DIPS is 3,5-diisopropylsalicylate and DMP is 2,9-dimethylphenanthroline) with human blood plasma and urine have been studied by 500 MHz 1H NMR spectroscopy, and CD spectroscopy has been used to...
Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
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