NMR paper Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

		BioNMR > Educational resources > Journal club
[NMR paper] Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

View First Unread

Thread Tools

Search this Thread

Rate Thread

Display Modes

07-11-2020, 03:34 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,174

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

Enzymatically Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors to Selectively Kill Cancer Cells

Angewandte Chemie International Edition, EarlyView.

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
[NMR paper] Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells Enzymatically-Formed Peptide Assemblies Sequestrate Proteins and Relocate Inhibitors for Selectively Killing Cancer Cells Angewandte Chemie International Edition, Accepted Article. More...	nmrlearner	Journal club	0	06-11-2020 06:01 PM
At last, cancer-fighting inhibitors hit deubiquitinase target selectively ... - The Biological SCENE http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcSlwrRUX7xpKKGSxiyVp-aDOn7FaGqLt1se2PdgSOeSxwFGBqwI7vwb_JUFZ9UCSr0B2gZNF68 The Biological SCENE <img alt="" height="1" width="1"> At last, cancer-fighting inhibitors hit deubiquitinase target selectively ... The Biological SCENE In the body, ubiquitinating enzymes regulate proteinsâ??marking them for disposal, for exampleâ??by adding ubiquitin peptides to them. And deubiquitinases ... and more » At last, cancer-fighting inhibitors hit deubiquitinase target selectively ... - The Biological SCENE	nmrlearner	Online News	0	10-22-2017 04:54 PM
The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc)Is an Enzymatically Stable and Reasonable Structural Surrogate forO-GlcNAc at the Peptide and Protein Levels The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc)Is an Enzymatically Stable and Reasonable Structural Surrogate forO-GlcNAc at the Peptide and Protein Levels http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00268/20170630/images/medium/bi-2017-00268h_0008.gif Biochemistry DOI: 10.1021/acs.biochem.7b00268 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/h4Fn-T3dtBo More...	nmrlearner	Journal club	0	07-01-2017 11:41 AM
[NMR paper] Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR. Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR. http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR. Bioconjug Chem. 2016 Aug 17;27(8):1796-801 Authors: Jeong K, Netirojjanakul C, Munch HK, Sun J, Finbloom JA, Wemmer DE, Pines A, Francis MB Abstract We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a...	nmrlearner	Journal club	0	06-20-2017 04:14 PM
Novel protein inhibitors engineered as alternative approach to potentially treat cancer - Science Daily http://www.bionmr.com//t1.gstatic.com/images?q=tbn:ANd9GcTArx6QDkt_eys4vsBX6AKLFWNV35-5QEwADhFv6KBkEJhgPFqbiubXiOnuko403fIt--H0YDcs Science Daily <img alt="" height="1" width="1"> Novel protein inhibitors engineered as alternative approach to potentially treat cancer Science Daily Superimposed ribbon structures of N-TIMP-1 extracted from 3D structures of complexes with different MMPs determined by X-ray crystallography, and two structures of the free protein in solution determined by nuclear magnetic resonance spectroscopy. Novel protein inhibitors engineered as alternative...	nmrlearner	Online News	0	06-07-2016 02:39 PM
Researchers take snapshots of potential â??kill switchâ?? for cancer - R & D Magazine http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcR87J_OrLBj1SG4hMIOlKdnTUiJd8twYYWLJIdivIZ7nUCqwaw-Rq3P-7owCzgW7gmEldpO_zid R & D Magazine <img alt="" height="1" width="1" /> Researchers take snapshots of potential â??kill switchâ?? for cancer R & D Magazine To find out more, the research team first used a technique known as nuclear magnetic resonance spectroscopy, or NMR, to analyze how the protein domains move in the closed state, and followed up with studies at SSRL, where they observed how x-rays ... and more » Researchers take snapshots of potential â??kill...	nmrlearner	Online News	0	11-12-2014 01:50 AM
Robust and low cost uniform 15N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications Robust and low cost uniform 15N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications Publication date: Available online 28 August 2014 Source:Journal of Structural Biology</br> Author(s): Annalisa Meola , Célia Deville , Scott A. Jeffers , Pablo Guardado-Calvo , Ieva Vasiliauskaite , Christina Sizun , Christine Girard-Blanc , Christian Malosse , Carine van Heijenoort , Julia Chamot-Rooke , Thomas Krey , Eric Guittet , Stéphane Pêtres , Félix A. Rey , François Bontems</br> Nuclear magnetic...	nmrlearner	Journal club	0	08-29-2014 05:36 PM
Solid-State NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. Solid-State NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Solid-State NMR characterization of autofluorescent fibrils formed by the elastin-derived peptide GVGVAGVG. Biomacromolecules. 2011 May 9;12(5):1546-55 Authors: Sharpe S, Simonetti K, Yau J, Walsh P Abstract The characterization of the molecular structure and physical properties of self-assembling peptides is an...	nmrlearner	Journal club	0	09-10-2011 06:51 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off