Dynamics of Biomolecules from Picoseconds to Seconds at Atomic Resolution
 

Dynamics of Biomolecules from Picoseconds to Seconds at Atomic Resolution


Publication year: 2011
Source: Journal of Magnetic Resonance, In Press, Accepted Manuscript, Available online 22 July 2011</br>
Dennis A., Torchia</br>
Although biomolecular dynamics has been investigated using NMR for at least 40 years, only in the past 20 years have internal motions been characterized at atomic resolution throughout proteins and nucleic acids. This development was made possible by multidimensional heteronuclear NMR approaches that provide near complete sequential signal assignments of uniformly labeled biomolecules. Recent methodological advances have enabled characterization of internal dynamics on timescales ranging from picoseconds to seconds, both in solution and in the solid state. The size, complexity and functional significance of biomolecules investigated by NMR continue to grow, as do the insights that have been obtained about...</br>
As depicted schematically, stochastic motions on timescales ranging from ps to seconds are revealed by various NMR experiments in solution and in solids.
http://www.sciencedirect.com/cache/M...JX-53CK3Y8-2-2</br></br>

Source: Journal of Magnetic Resonance