[NMR paper] Detection of Lung Cancer via Blood Plasma and (1)H-NMR Metabolomics: Validation by a Semi-Targeted and Quantitative Approach Using a Protein-Binding Competitor
Detection of Lung Cancer via Blood Plasma and (1)H-NMR Metabolomics: Validation by a Semi-Targeted and Quantitative Approach Using a Protein-Binding Competitor
Metabolite profiling of blood plasma, by proton nuclear magnetic resonance (¹H-NMR) spectroscopy, offers great potential for early cancer diagnosis and unraveling disruptions in cancer metabolism. Despite the essential attempts to standardize pre-analytical and external conditions, such as pH or temperature, the donor-intrinsic plasma protein concentration is highly overlooked. However, this is of utmost importance, since several...
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08-27-2021 03:49 PM
[NMR paper] Comparison of Targeted (HPLC) and Nontargeted (GC-MS and NMR) Approaches for the Detection of Undeclared Addition of Protein Hydrolysates in Turkey Breast Muscle.
Comparison of Targeted (HPLC) and Nontargeted (GC-MS and NMR) Approaches for the Detection of Undeclared Addition of Protein Hydrolysates in Turkey Breast Muscle.
Related Articles Comparison of Targeted (HPLC) and Nontargeted (GC-MS and NMR) Approaches for the Detection of Undeclared Addition of Protein Hydrolysates in Turkey Breast Muscle.
Foods. 2020 Aug 08;9(8):
Authors: Wagner L, Peukert M, Kranz B, Gerhardt N, Andrée S, Busch U, Brüggemann DA
Abstract
The adulteration of fresh turkey meat by the undeclared addition of...
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08-15-2020 05:51 AM
[ASAP] Unlocking a Diazirine Long-Lived Nuclear Singlet State via Photochemistry: NMR Detection and Lifetime of an Unstabilized Diazo-Compound
Unlocking a Diazirine Long-Lived Nuclear Singlet State via Photochemistry: NMR Detection and Lifetime of an Unstabilized Diazo-Compound
Barbara Procacci, Soumya S. Roy, Philip Norcott, Norman Turner, Simon B. Duckett
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.8b10923/20181121/images/medium/ja-2018-10923h_0015.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.8b10923
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/tCAAHsCnPe4
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11-25-2018 06:02 AM
[NMR paper] Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy.
Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy.
Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy.
Anal Chem. 2014 Dec 8;
Authors: Nagana Gowda GA, Gowda YN, Raftery D
Abstract
A current challenge in metabolomics is the reliable quantitation of many metabolites. Limited resolution and sensitivity combined with the challenges associated with unknown metabolite identification have restricted both the number and the quantitative accuracy of blood metabolites....
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12-09-2014 01:13 PM
HNCA+, HNCO+, and HNCACB+ experiments: improved performance by simultaneous detection of orthogonal coherence transfer pathways
HNCA+, HNCO+, and HNCACB+ experiments: improved performance by simultaneous detection of orthogonal coherence transfer pathways
Abstract
Three experiments, BESTâ??TROSY HNCA+, HNCO+ and HNCACB+ are presented for sequential backbone resonance assignment of 13C, 15N labelled proteins. The novelty of these experiments with respect to conventional pulse sequences is the detection of additional orthogonal coherence transfer pathways that results in enhanced sensitivity for sequential correlations without significantly compromising the intensity of...
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07-25-2014 03:12 AM
Systematic Study of Protein Detection Mechanism of Self-Assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity
Systematic Study of Protein Detection Mechanism of Self-Assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity
Yousuke Takaoka, Keishi Kiminami, Keigo Mizusawa, Kazuya Matsuo, Michiko Narazaki, Tetsuya Matsuda and Itaru Hamachi
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja203996c/aop/images/medium/ja-2011-03996c_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja203996c
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/fqTSjFalrGg
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07-12-2011 08:16 AM
[NMR paper] Design of small volume HX and triple-resonance probes for improved limits of detectio
Design of small volume HX and triple-resonance probes for improved limits of detection in protein NMR experiments.
Related Articles Design of small volume HX and triple-resonance probes for improved limits of detection in protein NMR experiments.
J Magn Reson. 2003 Sep;164(1):128-35
Authors: Li Y, Logan TM, Edison AS, Webb A
Three- and four-frequency nuclear magnetic-resonance probes have been designed for the study of small amounts of protein. Both "HX" (1H, X, and 2H channels) and "triple-resonance" (1H, 15N, 13C, and 2H) probes were...
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11-24-2010 09:16 PM
Clean STD-NMR spectrum for improved detection of ligand-protein interactions at low c
Clean STD-NMR spectrum for improved detection of ligand-protein interactions at low concentration of protein.
Related Articles Clean STD-NMR spectrum for improved detection of ligand-protein interactions at low concentration of protein.
Magn Reson Chem. 2010 Oct 18;
Authors: Xia Y, Zhu Q, Jun KY, Wang J, Gao X
Saturation transfer difference (STD)-NMR has been widely used to screen ligand compound libraries for their binding activities to proteins and to determine the binding epitopes of the ligands. We report herein, a Clean STD-NMR method...
DREAMTIME NMR Spectroscopy: Targeted Multi-Compound Selection with Improved Detection Limits
Linear Mode
