The Disordered EZH2 Loop: Atomic Level Characterization by 1HN- and 1H?-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA
 

The Disordered EZH2 Loop: Atomic Level Characterization by 1HN- and 1H?-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA

The 96-residue-long loop of EZH2 is proposed to play a role in the interaction with long non-coding RNAs (lncRNAs) and to contribute to EZH2 recruitment to the chromatin. However, molecular details of RNA recognition have not been described so far. Cellular studies have suggested that phosphorylation of the Thr345 residue localized in this loop influences RNA binding; however, no mechanistic explanation has been offered. To address these issues, a systematic NMR study was performed. As the...

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