Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR
 

Determining the Physico-Chemical Composition of Biomolecular Condensates from Spatially-Resolved NMR

Liquid-Liquid phase separation has emerged as fundamental process underlying the formation of biomolecular condensates. Insights into the composition and structure of biomolecular condensates is, however, complicated by their molecular complexity and dynamics. Here, we introduce an improved spatially-resolved NMR experiment that enables quantitative analysis of the physico-chemical composition of multi-component biomolecular condensates in equilibrium and label-free. Application of...

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