Deciphering the Binding Interactions between Acinetobacter baumannii ACP and beta-ketoacyl ACP Synthase III to Improve Antibiotic Targeting Using NMR Spectroscopy
 

Deciphering the Binding Interactions between Acinetobacter baumannii ACP and beta-ketoacyl ACP Synthase III to Improve Antibiotic Targeting Using NMR Spectroscopy

Fatty acid synthesis is essential for bacterial viability. Thus, fatty acid synthases (FASs) represent effective targets for antibiotics. Nevertheless, multidrug-resistant bacteria, including the human opportunistic bacteria, Acinetobacter baumannii, are emerging threats. Meanwhile, the FAS pathway of A. baumannii is relatively unexplored. Considering that acyl carrier protein (ACP) has an important role in the delivery of fatty acyl intermediates to other FAS enzymes, we elucidated the solution...

More...