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nmrlearner 03-24-2015 09:58 PM

The contribution of solid-state NMR spectroscopy to understanding biomineralization: Atomic and molecular structure of bone.
 
The contribution of solid-state NMR spectroscopy to understanding biomineralization: Atomic and molecular structure of bone.

http://www.bionmr.com//www.ncbi.nlm....PubMedLink.gif The contribution of solid-state NMR spectroscopy to understanding biomineralization: Atomic and molecular structure of bone.

J Magn Reson. 2015 Apr;253:98-110

Authors: Duer MJ

Abstract
Solid-state NMR spectroscopy has had a major impact on our understanding of the structure of mineralized tissues, in particular bone. Bone exemplifies the organic-inorganic composite structure inherent in mineralized tissues. The organic component of the extracellular matrix in bone is primarily composed of ordered fibrils of collagen triple-helical molecules, in which the inorganic component, calcium phosphate particles, composed of stacks of mineral platelets, are arranged around the fibrils. This perspective argues that key factors in our current structural model of bone mineral have come about through NMR spectroscopy and have yielded the primary information on how the mineral particles interface and bind with the underlying organic matrix. The structure of collagen within the organic matrix of bone or any other structural tissue has yet to be determined, but here too, this perspective shows there has been real progress made through application of solid-state NMR spectroscopy in conjunction with other techniques. In particular, NMR spectroscopy has highlighted the fact that even within these structural proteins, there is considerable dynamics, which suggests that one should be cautious when using inherently static structural models, such as those arising from X-ray diffraction analyses, to gain insight into molecular roles. It is clear that the NMR approach is still in its infancy in this area, and that we can expect many more developments in the future, particularly in understanding the molecular mechanisms of bone diseases and ageing.


PMID: 25797009 [PubMed - in process]



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