Complexes of Bifunctional DO3A-N-(alpha-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies
 

Complexes of Bifunctional DO3A-N-(alpha-amino)propinate Ligands with Mg(II), Ca(II), Cu(II), Zn(II), and Lanthanide(III) Ions: Thermodynamic Stability, Formation and Dissociation Kinetics, and Solution Dynamic NMR Studies

The thermodynamic, kinetic, and structural properties of Ln^(3+) complexes with the bifunctional DO3A-ACE^(4-) ligand and its amide derivative DO3A-BACE^(4-) (modelling the case where DO3A-ACE^(4-) ligand binds to vector molecules) have been studied in order to confirm the usefulness of the corresponding Gd^(3+) complexes as relaxation labels of targeted MRI contrast agents. The stability constants of the Mg^(2+) and Ca^(2+) complexes of DO3A-ACE^(4-) and DO3A-BACE^(4-) complexes are lower than...

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