A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues.
 

A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues.

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Angew Chem Int Ed Engl. 2013 Aug 22;

Authors: Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith MJ, Ikura M, Kay LE

Abstract
Conformational Exchange: Small GTPases, such as Ras and Rheb, exchange between major and minor conformers when bound to GTP, with different functional properties for each state. Two-dimensional (15) N CEST NMR spectroscopy is used to quantify the exchange parameters for both Ras and Rheb complexed with physiological GTP and the analogues GTP?S and GppNHp.


PMID: 24039022 [PubMed - as supplied by publisher]



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