Clustering of tetrameric influenza M2 peptides in lipid bilayers investigated by (19)F solid-state NMR
 

Clustering of tetrameric influenza M2 peptides in lipid bilayers investigated by (19)F solid-state NMR

The influenza M2 protein forms a drug-targeted tetrameric proton channel to mediate virus uncoating and carries out membrane scission to mediate virus release. While the proton channel function of M2 has been extensively studied, the mechanism by which M2 conducts membrane scission is still not well understood. Previous fluorescence and electron microscopy studies indicated that M2 tetramers concentrate at the neck of the budding virus in the host plasma membrane. However, molecular evidence for...

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