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Default Characterization of fibril dynamics on three timescales by solid-state NMR

Characterization of fibril dynamics on three timescales by solid-state NMR

Abstract

A multi-timescale analysis of the backbone dynamics of HET-s (218â??289) fibrils is described based on multiple site-specific R 1 and R 1Ï? data sets and S 2 measurements via REDOR for most backbone 15N and 13Cα nuclei. 15N and 13Cα data are fitted with motions at three timescales. Slow motion is found, indicating a global fibril motion. We further investigate the effect of 13Câ??13C transfer in measurement of 13Cα R 1. Finally, we show that it is necessary to go beyond the Redfield approximation for slow motions in order to obtain accurate numerical values for R 1Ï?.



Source: Journal of Biomolecular NMR
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