CONCLUSION: Using a combination of LC-MS and NMR methodologies we identified several altered mechanisms possibly related to AD pathology. EVs require additional optimization prior to their possible utilization as a biological material for AD-related metabolomics studies.
This Is The Closest Look We've Ever Had at The Proteins Linked to Alzheimer's Disease - ScienceAlert
This Is The Closest Look We've Ever Had at The Proteins Linked to Alzheimer's Disease - ScienceAlert
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ScienceAlert
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This Is The Closest Look We've Ever Had at The Proteins Linked to Alzheimer's Disease
ScienceAlert
Extra readings from solid-state nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction experiments helped to validate the data and the atomic structure, producing a computer rendering that's the most...
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09-12-2017 01:45 PM
[NMR paper] NMR spectroscopy-based metabolomics of Drosophila model of Huntington's disease suggests altered cell energetics.
NMR spectroscopy-based metabolomics of Drosophila model of Huntington's disease suggests altered cell energetics.
Related Articles NMR spectroscopy-based metabolomics of Drosophila model of Huntington's disease suggests altered cell energetics.
J Proteome Res. 2017 Sep 05;:
Authors: Singh V, Sharma RK, Athilingam T, Sinha P, Sinha N, Thakur AK
Abstract
Huntington's disease (HD) is a neurodegenerative disorder induced by aggregation of the pathological form of Huntingtin protein that has expanded polyglutamine (polyQ) repeats. In...
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09-06-2017 04:13 PM
Ion Channel Formation by Tau Protein: Implicationsfor Alzheimer’s Disease and Tauopathies
Ion Channel Formation by Tau Protein: Implicationsfor Alzheimer’s Disease and Tauopathies
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.5b00988/20151201/images/medium/bi-2015-009883_0006.gif
Biochemistry
DOI: 10.1021/acs.biochem.5b00988
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12-07-2015 06:38 PM
Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com
Plasma protein biomarkers of Alzheimer's disease endophenotypes in ... - Nature.com
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Plasma protein biomarkers of Alzheimer's disease endophenotypes in ...
Nature.com
Volumes of the hippocampi and entorhinal cortices in the ANM cohort were obtained using FreeSurfer 5.1.0 (freely available from http://surfer.nmr.mgh.harvard.edu/) from 276 ANM subjects who had undergone structural MRI. These regions were selected as ...
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06-16-2015 07:24 PM
[NMR paper] Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid ?-fibrils in a redox cycle.
Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid ?-fibrils in a redox cycle.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-standard-jbc_final.gif Related Articles Capturing a reactive state of amyloid aggregates: NMR-based characterization of copper-bound Alzheimer disease amyloid ?-fibrils in a redox cycle.
J Biol Chem. 2014 Apr 4;289(14):9998-10010
Authors: Parthasarathy S, Yoo B, McElheny D, Tay W,...
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05-31-2014 01:57 PM
Alzheimer's disease: NMR pinpoints genetic clue
Alzheimer's disease: NMR pinpoints genetic clue
http://www.spectroscopynow.com/common/images/thumbnails/1438cadfde3.jpgResearchers have turned to solution NMR spectroscopy to help them characterise the structure and dynamics of the transmembrane portion of the protein amyloid precursor protein, APP, of which there are two genetic variants linked to familial, or hereditary Alzheimer's disease.
Read the rest at Spectroscopynow.com
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01-15-2014 05:05 AM
[NMR paper] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
Related Articles NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
J Clin Biochem Nutr. 2013 Mar;52(2):133-8
Authors: Fukuhara K, Ohno A, Ota Y, Senoo Y, Maekawa K, Okuda H, Kurihara M, Okuno A, Niida S, Saito Y, Takikawa O
Abstract
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker...
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03-26-2013 01:30 PM
Alzheimer's analysed: New clues in brain disease
Alzheimer's analysed: New clues in brain disease
http://www.spectroscopynow.com/common/images/thumbnails/13af4d7f690.jpgRecent studies have added weight to the idea that amyloid-beta is a causative agent in Alzheimer's disease rather than the plaques formed from these chunks of misfolded peptide that deposit in the diseased brain. Now, European researchers have used REAPDOR solid-state NMR spectroscopy to analyse the hydrogen bonds in the tiny fibrils of amyloid-beta peptide, offering another perspective on this neurodegenerative disorder.
Source: Spectroscopynow.com
Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
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