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-   -   [NMR paper] The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring. (http://www.bionmr.com/forum/journal-club-9/c-terminal-cytidine-deaminase-domain-apobec3g-itself-undergoes-intersegmental-transfer-target-search-revealed-real-time-nmr-monitoring-25734/)

nmrlearner 02-27-2018 12:30 PM

The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring.
 
The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring.

http://www.bionmr.com//www.ncbi.nlm...._z_RSClogo.gif Related Articles The C-terminal cytidine deaminase domain of APOBEC3G itself undergoes intersegmental transfer for a target search, as revealed by real-time NMR monitoring.

Phys Chem Chem Phys. 2018 Jan 31;20(5):2976-2981

Authors: Kamba K, Nagata T, Katahira M

Abstract
APOBEC3G (A3G), an anti-human immunodeficiency virus 1 factor, deaminates cytidines. We examined deamination of two cytidines located separately on substrate ssDNA by the C-terminal domain (CTD) of A3G using real-time NMR monitoring. The deamination preference between the two cytidines was lost when either the substrate or non-substrate ssDNA concentration increased. When the non-substrate ssDNA concentration increased, the deamination activity first increased, but then decreased. This indicates that even a single domain, A3G-CTD, undergoes intersegmental transfer for a target search.


PMID: 28905055 [PubMed - indexed for MEDLINE]



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