Boosting the resolution of multidimensional NMR spectra by complete removal of proton spin multiplicities
 

Boosting the resolution of multidimensional NMR spectra by complete removal of proton spin multiplicities

Over decades multidimensional NMR spectroscopy has become an indispensable tool for structure elucidation of natural products, peptides and medium sized to large proteins. Heteronuclear single quantum coherence (HSQC) spectroscopy is one of the work horses in that field often used to map structural connectivity between protons and carbons or other hetero nuclei. In overcrowded HSQC spectra, proton multiplet structures of cross peaks set a limit to the power of resolution and make a...

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