Biomolecular magic-angle spinning solid-state NMR: recent methods and applications.
 

Biomolecular magic-angle spinning solid-state NMR: recent methods and applications.

Related Articles Biomolecular magic-angle spinning solid-state NMR: recent methods and applications.

Curr Opin Biotechnol. 2013 Mar 4;

Authors: Goldbourt A

Abstract
The link of structure and dynamics of biomolecules and their complexes to their function and to many cellular processes has driven the quest for their detailed characterization by a variety of biophysical techniques. Magic-angle spinning solid-state nuclear magnetic resonance spectroscopy provides detailed information on the structural properties of such systems and in particular contributes invaluable information on non-soluble, large molecular-weight and non-crystalline biomolecules. This review summarizes the recent progress that has been made in the characterization of macromolecular assemblies, viruses, membrane proteins, amyloid fibrils, protein aggregates and more by magic-angle spinning solid-state NMR.


PMID: 23481376 [PubMed - as supplied by publisher]



More...