Biological findings from the recent NMR-based studies of glycosaminoglycanprotein interactions.
 

Biological findings from the recent NMR-based studies of glycosaminoglycanprotein interactions.

Related Articles Biological findings from the recent NMR-based studies of glycosaminoglycanprotein interactions.

Glycobiology. 2014 Jun 27;

Authors: Pomin VH

Abstract
Besides regulating multiple physiological processes like cellular growth, migration and differentiation, glycosaminoglycans (GAGs) are also largely explored in the global market as clinical or nutraceutical agents. Generally, these physiological and biomedical events are ultimately triggered by the quality and nature of molecular interactions between GAGs and functional proteins. Nuclear magnetic resonance (NMR) spectroscopy participates significantly in the investigations of the most carbohydrate-protein interactions. The present review covers in a very systematic and comprehensive way the major NMRbased works of GAG-protein interactions undertaken within the last three years. The main objective herein is, besides revisiting the results from these recent NMR-based GAG-protein works, to present for the current glycomic era an overview about the underlying biological inferences drawn from these results.


PMID: 24973916 [PubMed - as supplied by publisher]



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