Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR [Biophysics and Computational Biology]
Binding kinetics and substrate selectivity in HIV-1 protease-Gag interactions probed at atomic resolution by chemical exchange NMR [Biophysics and Computational Biology]
Lalit Deshmukh, Vitali Tugarinov, John M. Louis, G. Marius Clore... Date: 2017-11-14 The conversion of immature noninfectious HIV-1 particles to infectious virions is dependent upon the sequential cleavage of the precursor group-specific antigen (Gag) polyprotein by HIV-1 protease. The precise mechanism whereby protease recognizes distinct Gag cleavage sites, located in the intrinsically disordered linkers connecting the globular domains of Gag, remains unclear.... Read More PNAS: Number: 46 Volume: 114 |
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