Applications of solid-state NMR to membrane proteins
Applications of solid-state NMR to membrane proteins
Publication date: Available online 12 July 2017 Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics</br> Author(s): Vladimir Ladizhansky</br> Membrane proteins mediate flow of molecules, signals, and energy between cells and intracellular compartments. Understanding membrane protein function requires a detailed understanding of the structural and dynamic properties involved. Lipid bilayers provide a native-like environment for structure-function investigations of membrane proteins. In this review we give a general discourse on the recent progress in the field of solid-state NMR of membrane proteins. Solid-state NMR is a variation of NMR spectroscopy that is applicable to molecular systems with restricted mobility, such as high molecular weight proteins and protein complexes, supramolecular assemblies, or membrane proteins in a phospholipid environment. We highlight recent advances in applications of solid-state NMR to membrane proteins, specifically focusing on the recent developments in the field of Dynamic Nuclear Polarization, proton detection, and solid-state NMR applications in situ (in cell membranes). This article is part of a Special Issue entitled: Biophysics in Canada, edited by Lewis Kay, John Baenziger, Albert Berghuis and Peter Tieleman. Graphical abstract http://origin-ars.els-cdn.com/conten...301516-fx1.jpg</br></br> </br></br> More... |
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