[NMR paper] Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion
Mapping the energy landscape of protein-ligand binding via linear free energy relationships determined by protein NMR relaxation dispersion
Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand-receptor complex. In the field of drug design, the recognition that drug efficacy in vivo depends on the lifetime of the drug-protein complex has spawned the concept of designing drugs with particular binding kinetics. To advance this field it is critical to investigate...
[NMR paper] Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange.
Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange.
Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange.
J Phys Chem Lett. 2018 Jun 04;:
Authors: Xu D, Li B, Gao J, Liu Z, Niu X, Nshogoza G, Zhang J, Wu J, Su XC, He W, Ma R, Yang D, Ruan K
Abstract
Delineation of protein-ligand interaction modes is key for rational drug discovery. The availability of complex crystal structures...
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06-05-2018 01:31 PM
T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C
From The DNP-NMR Blog:
T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C
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Martinez-Santiesteban, F.M., et al., T1 nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13 C. NMR Biomed, 2017. 30(9): p. e3749-n/a.
https://www.ncbi.nlm.nih.gov/pubmed/28653507
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10-16-2017 03:30 PM
Journal Highlight: T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C
Journal Highlight: T1 Nuclear magnetic relaxation dispersion of hyperpolarized sodium and cesium hydrogencarbonate-13C
http://www.spectroscopynow.com/common/images/thumbnails/15e48ec1e0e.jpgThe T1 dispersion from low to clinical magnetic fields of different hyperpolarized hydrogencarbonate formulations previously proposed in the literature for in vivo pH measurements has been measured to aid pH mapping in tissue.
Read the rest at Spectroscopynow.com
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09-04-2017 03:11 PM
[NMR paper] Measurement of Ligand-Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy.
Measurement of Ligand-Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy.
Related Articles Measurement of Ligand-Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy.
J Med Chem. 2016 Dec 08;59(23):10788-10793
Authors: Moschen T, Grutsch S, Juen MA, Wunderlich CH, Kreutz C, Tollinger M
Abstract
A ligand-observed (1)H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does...
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12-11-2016 06:23 AM
[NMR paper] Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1 -RNA Binding.
Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1 -RNA Binding.
Related Articles Ligand-Detected Relaxation Dispersion NMR Spectroscopy: Dynamics of preQ1 -RNA Binding.
Angew Chem Int Ed Engl. 2014 Nov 17;
Authors: Moschen T, Wunderlich CH, Spitzer R, Levic J, Micura R, Tollinger M, Kreutz C
Abstract
An NMR-based approach to characterizing the binding kinetics of ligand molecules to biomolecules, like RNA or proteins, by ligand-detected Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion experiments is...
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11-19-2014 04:32 PM
[NMR paper] Slow internal dynamics in proteins: application of NMR relaxation dispersion spectros
Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme.
Related Articles Slow internal dynamics in proteins: application of NMR relaxation dispersion spectroscopy to methyl groups in a cavity mutant of T4 lysozyme.
J Am Chem Soc. 2002 Feb 20;124(7):1443-51
Authors: Mulder FA, Hon B, Mittermaier A, Dahlquist FW, Kay LE
Recently developed carbon transverse relaxation dispersion experiments (Skrynnikov, N. R.; et al. J. Am. Chem. Soc. 2001, 123, 4556-4566) were...
Application of Relaxation Dispersion of Hyperpolarized 13C Spins to Protein-Ligand Binding
Linear Mode
