Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR
 

Analysis of the orientation of cholesterol in high-density lipoprotein nanodiscs using solid-state NMR

Cholesterol is an essential component of eukaryotic cellular membranes that regulates the order and phase behaviour of dynamic lipid bilayers. Although cholesterol performs many vital physiological roles, hypercholesterolaemia and the accumulation of cholesterol in atherosclerotic plaques can increase the risk of coronary heart disease morbidity. The risk is mitigated by the transportation of cholesterol from peripheral tissue to the liver by high-density lipoprotein (HDL), 6-20 nm-diameter...

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