Aligned peptoid-based macrodiscs for structural studies of membrane proteins by oriented-sample nmr
 

ALIGNED PEPTOID-BASED MACRODISCS FOR STRUCTURAL STUDIES OF MEMBRANE PROTEINS BY ORIENTED-SAMPLE NMR

Development of a robust, uniform, and magnetically orientable lipid mimetics will undoubtedly advance solid-state NMR of macroscopically aligned membrane proteins. Here we report on a novel lipid membrane mimetic based on peptoid belts. The peptoids composed of 15 residues were synthesized by alternating N-(2-carboxyethyl)glycine with N-(2-phenethyl)glycine residues at the 2:1 molar ratio. The chemically synthesized peptoids possess much lower degree of polydispersity as compared to...

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