The advanced properties of circularized MSP nanodiscs facilitate high-resolution NMR studies of membrane proteins
 

The advanced properties of circularized MSP nanodiscs facilitate high-resolution NMR studies of membrane proteins

Membrane mimetics are essential for structural and functional studies of membrane proteins. A promising lipid-based system are phospholipid nanodiscs, where two copies of a so-called membrane scaffold protein (MSP) wrap around a patch of lipid bilayer. Consequently, the size of a nanodisc is determined by the length of the MSP. Furthermore, covalent MSP circularization was reported to improve nanodisc stability. However, a more detailed comparative analysis of the biophysical properties of...

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